Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment (NCT07529145) | Clinical Trial Compass
RecruitingNot Applicable
Cardiopulmonary Exercise Testing in Lung Cancer Patients Before and During Oncological Treatment
Poland90 participantsStarted 2026-01-01
Plain-language summary
Patients with lung cancer often have reduced physical fitness and coexisting health problems, which may limit their ability to tolerate oncological treatment. Standard resting lung and heart tests do not always reflect real-life physical capacity during everyday activities or physical effort.
This observational study aims to assess cardiorespiratory fitness in patients with lung cancer before and during standard oncological treatment using cardiopulmonary exercise testing (CPET). CPET is a safe, supervised exercise test that provides objective information on how the heart, lungs, and muscles respond to physical effort.
Participants with WHO/ECOG performance status 0-2 will undergo CPET before treatment initiation and again after the early phase of therapy or surgery. The results may help identify patients with reduced physiological reserve and support individualized monitoring during routine clinical care.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥ 18 years
* Histologically confirmed lung cancer (any stage)
* Qualified for standard oncological management (surgery and/or systemic therapy)
* WHO/ECOG performance status 0-2
* Ability to perform cardiopulmonary exercise testing (CPET)
* Written informed consent
Exclusion Criteria:
* Unstable ischemic heart disease
* Symptomatic cardiac arrhythmias
* Myocarditis or pericarditis
* Decompensated heart failure
* Active deep vein thrombosis
* Suspected aortic dissection or severe aortic stenosis
* Poorly controlled asthma
* Resting oxygen saturation ≤ 85% on room air
* Clinically relevant treatment-related adverse events above mild intensity (as applicable)
* Any medical condition that, in the investigator's opinion, precludes safe participation in CPET
* Withdrawal of informed consent
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in peak oxygen uptake (VO2peak) measured by cardiopulmonary exercise testing
Timeframe: Baseline and 6-8 weeks after treatment initiation or approximately 6 weeks after surgery