Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques (NCT07527793) | Clinical Trial Compass
RecruitingNot Applicable
Monitoring Changes in Blood Circulating Metabolites Using Minimally Invasive Techniques
Sweden35 participantsStarted 2026-01-21
Plain-language summary
This study investigates short-term intra- and inter-individual variability in human blood metabolism under real-life conditions. Using minimally invasive finger-prick blood sampling, dietary records, and wearable devices, we will longitudinally monitor blood-circulating metabolites and glucose levels in healthy individuals over a four-week period without dietary or lifestyle intervention. The study focuses on metabolic transitions between pre- and postprandial states during habitual daily activities and routine meals. Mass spectrometry-based metabolomics will be used to characterize metabolite profiles and their associations with diet, physical activity, sleep, and stress. In parallel, the study evaluates the feasibility of microsampling approaches, wearable-derived physiological data, and isotope-labelled standards for robust and cost-effective metabolite quantification. The results will inform the design of larger longitudinal studies using minimally invasive blood sampling in non-controlled settings.
Who can participate
Age range18 Years – 65 Years
SexALL
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Inclusion criteria
✓. Age: 18-65 years old
✓. Body Mass Index (BMI): 18.5-29.9 kg/m2
✓. Weight stability within the previous 3 months (self-reported).
✓. Positive intention to maintain usual routine physical activity and eating habits during the study.
Exclusion criteria
✕. Presence of acute chronic diseases, inflammatory or functional gastrointestinal disorders, or any diagnosed disease condition that disrupt daily routine activities.
✕. Routine use medications or supplements that could potentially interfere with the study outcomes
✕. History of eating disorder
✕. Recent use of antibiotic medication within the last 3 months prior to the first visit