Nortriptyline and the Risk of Serious Adverse Events

Exclusion criteria

• ✕. Individuals with missing administrative database number, missing or invalid age (\<0 or \>105 years), missing or invalid sex, death on or before the index date, non-Ontario resident (for Ontario data), or non-Alberta residents (for Alberta data).
• ✕. Individuals less than 66 years of age on the index date.
• ✕. Those with evidence of any study drug prescription 180 days before the index date (to restrict to new users only).
• ✕. Individuals with more than one study drug prescription on the index date, as this complicates the ability to ascertain the prescribed dose accurately.
• ✕. Evidence of clinically non-meaningful nortriptyline doses (doses that are either too low or too high). The recommended nortriptyline dose range is 10 to 150 mg per day.
• ✕. Evidence of other tricyclic antidepressants in the previous 180 days (including index date).
• ✕. Individuals with end-stage renal disease, chronic dialysis, or a kidney transplant prior to the index date.
• ✕. Evidence with hospital discharge or emergency department visit in the two days prior to or on the index date to ensure a new outpatient prescription.