SYS6002 vs Chemotherapy in Patients With Locally Advanced or Metastatic Urothelial Carcinoma

Exclusion criteria

• ✕. History of severe cardiovascular disease within 6 months prior to randomization, including but not limited to:
• ✕. Severe cardiac rhythm or conduction abnormalities, such as ventricular arrhythmia and third-degree atrioventricular block requiring clinical intervention; corrected QT interval \> 480 ms by Fridericia method (Fridericia formula: QTcF = QT/RR\^0.33, RR = 60/heart rate);
• ✕. With history of myocardial infarction, unstable angina pectoris, angioplasty and coronary artery bypass surgery;
• ✕. New York Heart Association (NYHA) classification Grade III and above heart failure, and left ventricular ejection fraction (LVEF) \< 50% in the tests and examinations during the screening period;
• ✕. Ischemic or Hemorrhagic Stroke;
• ✕. Pulmonary Embolism Accident;
• ✕. Other clinically significant diseases:
• ✕. HbA1c \> 8%;