Active — Not RecruitingPhase 4

Lateral GBR Using Two Types of Membrane With a Combination of Allograft-xenograft

Lebanon10 participantsStarted 2025-03-10

Plain-language summary

Bone width is critical for successful implant placement, as thin bone increases the risk of bone loss. Various augmentation techniques-especially guided bone regeneration (GBR)-are effective in restoring bone volume using grafts and barrier membranes. Collagen membranes are commonly used but degrade quickly, leading to the development of improved types like porcine peritoneum membranes, which show better strength and durability. While autogenous grafts are the gold standard, combining different graft materials (e.g., xenograft and allograft) has shown promising results. However, no studies have directly compared porcine peritoneum membranes with cross-linked membranes using such graft combinations. This study aims to evaluate and compare their effectiveness in increasing bone width.

Who can participate

Age range20 Years – 75 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * \- Patients aged 20 to 75 years. * Healthy individuals, either non-smokers or smokers consuming fewer than 10 cigarettes per day. * Full mouth bleeding score (FmBS) below 20%. * Full mouth plaque score (FmPS) below 15%. * Presence of a residual alveolar ridge with a bone width of less than 6 mm but sufficient bone height in the maxilla or mandible. * Tooth extraction must have been performed at least six weeks prior to surgery. * Adequate number of teeth to allow for the use of an occlusal stent or radiographic guide. Exclusion Criteria: * \- Presence of systemic illnesses. * Smoking more than 10 cigarettes per day. * Underwent radiotherapy in the head or neck region within the past 5 years. * Active periodontitis affecting the remaining teeth. * Pregnancy. * Use of medications that could impact bone turnover or mucosal healing, such as tetracycline in the last month, steroids within the past 6 months, bisphosphonates, therapeutic doses of fluorides, or vitamin D and its metabolites within the last 6 months.

What they're measuring

Compare the linear and volumetric bone width changes, clinically and radiographically, between two different membranes : glutaraldehyde cross-linked collagen membrane and a peritonium-derived membrane with the use of a bone graft combination of demineral

Timeframe: From March 2025 to March 2026

Trial details

NCT IDNCT07525128

SponsorSaint-Joseph University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-04-15