Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial (NCT07524335) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Aspirin in Subclinical Coronary Artery Disease: A Pilot Randomised Controlled Trial
Canada48 participantsStarted 2026-05-01
Plain-language summary
In patients with subclinical coronary artery disease, the ASCAD-P study aims to assess the feasibility of a larger phase 3 pragmatic randomized controlled trial comparing prescription versus no prescription of low-dose aspirin in routine clinical practice.
Who can participate
Age range40 Years
SexALL
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Inclusion criteria
✓. Documented coronary atherosclerosis, as defined by one of the following criteria:
✓. Coronary artery calcium (CAC) score \> 0;
✓. Cardiac CT angiography (CCTA) / CoroScan: lesions \<70% in the right coronary (RCA), left anterior descending (LAD), and circumflex (Cx) arteries or their branches, and \<50% in the left main coronary artery;
✓. Coronary angiography: lesions \<70% in the right coronary (RCA), left anterior descending (LAD), and circumflex (Cx) arteries or their branches, and \<50% in the left main coronary artery; if performed, physiological coronary assessments (FFR, dPR, iFR, etc.) and intracoronary imaging (IVUS or OCT) must be negative for significant disease.
✓. Willing and able to provide informed consent and comply with study procedures
Exclusion criteria
✕. History of myocardial infarction (MI), coronary revascularization, stroke, transient ischemic attack (TIA), or peripheral arterial revascularization procedure;
✕. Current prescription or clear indication for aspirin, low-molecular-weight heparin (LMWH), direct oral anticoagulants, or any other antithrombotic medication;
✕. Clear contraindication to aspirin;
✕. History of significant bleeding within the past year;
✕. Severe illness with limited life expectancy (i.e., \<5 years);
✕
What they're measuring
1
Monthly Recruitment Rate
Timeframe: 12 months following study enrollment initiation