Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery (NCT07523321) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery
China274 participantsStarted 2026-04
Plain-language summary
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP). In previous studies, perioperative use of dexmedetomidine or esketamine is each associated with improved analgesia after surgery. Recent studies suggest that combined use of dexmedetomidine and esketamine may produce synergetic effects in improving analgesia. This trial is designed to test the hypothesis that perioperative combined use of dexmedetomidine and esketamine may improve analgesia and reduce moderate-to-severe pain in patients after spinal surgery.
Who can participate
Age range40 Years – 80 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Aged \>= 40 years but \< 80 years;
✓. Scheduled to undergo elective posterior cervical, thoracic, or lumbar spine surgery with an expected duration \>= 2 hours under general anesthesia;
✓. Required patient-controlled intravenous analgesia (PCIA) after surgery.
✕. Severe bradycardia (heart rate \<= 50 bpm), sick sinus syndrome, atrioventricular block of grade II or higher without pacemaker implantation, a history of myocardial infarction within one year, or presence of rapid ventricular arrhythmia;
✕. History of schizophrenia, epilepsy, Parkinson's disease, or myasthenia gravis, or prresence of intracranial hypertension;
✕. Uncontrolled hyperthyroidism or pheochromocytoma;
✕. Inability to communicate due to coma, severe dementia, or language barrier;
What they're measuring
1
Incidence of moderate-to-severe pain within 72 hours after surgery
. Severe cardiac insufficiency (preoperative left ventricular ejection fraction \< 30% or New York Heart Association Functional classification IV), severe hepatic dysfunction (Child-Pugh class C), severe renal dysfunction (preoperative dialysis), or American Society of Anesthesiologists physical status \>= IV;
✕. Other conditions that are considered unsuitable for study participation.