i-PRF for Gingival Phenotype Modification (NCT07521527) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
i-PRF for Gingival Phenotype Modification
Turkey (Türkiye)20 participantsStarted 2026-04-01
Plain-language summary
This randomized split-mouth clinical trial aims to evaluate the effectiveness of injectable platelet-rich fibrin (i-PRF) in thickening thin gingival phenotype and improving soft tissue conditions around teeth.
Thin gingival tissue is an important risk factor for gingival recession and may negatively affect periodontal health and esthetic outcomes. This study investigates whether the use of i-PRF, obtained from the patient's own blood, can enhance gingival thickness and support tissue healing.
Following initial periodontal therapy, the procedure will be performed under local anesthesia. A minimally invasive approach will be applied to the gingival tissue, and i-PRF prepared from the patient's blood will be injected into the treatment area. The procedure will be repeated in multiple sessions at regular intervals. Patients will receive standard post-operative care and instructions.
Clinical parameters will be evaluated at follow-up visits, and gingival thickness will be measured using ultrasonography over a 6-month period.
Possible risks include mild pain, bleeding, infection, and temporary discomfort, all of which are manageable with routine clinical care.
This study is expected to contribute to the development of minimally invasive and biologically based treatment approaches, reduce the need for additional surgical procedures, and improve periodontal and esthetic outcomes.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Systemically healthy individuals aged ≥18 years
* Non-smokers or light smokers (≤10 cigarettes per day)
* Individuals with full-mouth plaque score (FMPS) \<15% and full-mouth bleeding score (FMBS) \<15%
* Individuals with gingival thickness \<0.8 mm in the mandibular anterior teeth to be treated
* Periodontally healthy individuals with probing depth (PD) ≤3 mm in the mandibular anterior teeth
* Absence of structural defects, crowns, or large restorations in the mandibular anterior teeth
* Absence of missing or supernumerary teeth in the mandibular anterior region
* No history of blood-borne infectious diseases
* No systemic diseases or medical conditions
Exclusion Criteria:
* Individuals under 18 years of age
* Pregnancy or breastfeeding
* Presence of periodontal pockets \>4 mm
* Presence of structural defects, crowns, or large restorations in the teeth
* Presence of systemic diseases or coagulation disorders
* Use of anticoagulant medications
* Ongoing orthodontic treatment with active tooth movement
* Use or history of medications affecting periodontal tissues (e.g., immunosuppressive drugs, calcium channel blockers, anticonvulsants)
* History of periodontal surgery in the area to be treated
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.