The goal of this randomized controlled study is to develop and validate an integrated neurophysiological model for predicting rehabilitation potential in patients with ischemic stroke. The study focuses on identifying objective markers of brain activity associated with motor preparation and recovery. The project includes two stages. First, healthy volunteers will participate in experimental motor and mental tasks to establish reference patterns of brain activity using electroencephalography and transcranial magnetic stimulation. These data will be used to define stable neurophysiological markers of motor network function. In the second stage, patients in the acute and early recovery phases after ischemic stroke will be randomly assigned to receive either active intermittent theta-burst stimulation of the motor cortex or a sham procedure, in addition to standard rehabilitation. Brain activity and clinical motor function will be assessed before and after the intervention. The study aims to determine which neurophysiological measures are sensitive to neuromodulation and are associated with clinical improvement, in order to construct a predictive model of rehabilitation outcome. Participants will \[describe the main tasks participants will be asked to do, interventions they'll be given and use bullets if it is more than 2 items\].
Age range
40 Years – 65 Years
Sex
ALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Muscle Strength Assessed by the Medical Research Council Scale (MRC)
Timeframe: Baseline and Week 2 (end of intervention, after 10 sessions of iTBS/Sham)
Change in Muscle Tone Assessed by the Modified Ashworth Scale (MAS)
Timeframe: Baseline and Week 2 (end of intervention, after 10 sessions of iTBS/Sham)
Change in Upper Limb Motor Function (Fugl-Meyer Assessment - Upper Extremity)
Timeframe: Baseline and Week 2 (end of intervention, after 10 sessions of iTBS/Sham)
Change in Cognitive Function Assessed by Montreal Cognitive Assessment (MoCA)
Timeframe: Baseline and Week 2 (end of intervention, after 10 sessions of iTBS/Sham)