Effects of High-Frequency Chest Wall Oscillation Combined With Concurrent Training on Cough,in Cy… (NCT07519460) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effects of High-Frequency Chest Wall Oscillation Combined With Concurrent Training on Cough,in Cystic Fibrosis Patients
Pakistan24 participantsStarted 2026-04
Plain-language summary
This randomized clinical trial aims to evaluate the effects of high-frequency chest wall oscillation (HFCWO) combined with concurrent training on cough, sputum clearance, exercise tolerance, and respiratory muscle strength in patients with Cystic Fibrosis. A total of 24 participants meeting inclusion criteria will be randomly allocated into two groups: Group A will receive HFCWO plus concurrent training, while Group B will receive HFCWO alone for 8 weeks. Outcomes will be measured before and after intervention using the 6-minute walk test, spirometry, Leicester Cough Questionnaire, sputum volume, and the Cystic Fibrosis Questionnaire-Revised. The study will be conducted at Pulmonary Rehabilitation Unit, Gulab Devi Hospital and Mayo Hospital, Lahore. Statistical analysis will be performed using IBM SPSS Statistics, with significance set at p \< 0.05.
Who can participate
Age range
16 Years – 35 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Diagnosed with Cystic Fibrosis, confirmed by genotype or sweat chloride \>60 mmol/L.
* Age 16-35 years.
* Both male and female participants.
* Stable clinical condition (no exacerbations in the last 2 weeks).
* Forced expiratory volume in 1 second (FEV₁ ≥ 20% predicted).
Exclusion Criteria:
* Active hemoptysis or pneumothorax.
* Risk of hemodynamic instability or severe hypoxia.
* Acute airway infection.
* Cognitive disorders affecting compliance.
* Pregnancy.
* Cardiac diseases such as heart failure or arrhythmias.
* Neurological or orthopedic illnesses or recent chest injury.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial combines high-frequency chest wall oscillation with concurrent training — how does that approach compare to the airway clearance and exercise routine I'm already doing, and could joining this study disrupt what's currently working for me?
2Since this trial is listed as 'not yet recruiting,' how long might it realistically be before it opens and patients can actually enroll, and should I be pursuing other options in the meantime?
3The trial is measuring changes in cough severity and exercise tolerance — given where my lung function and fitness stand right now, do you think those are the right goals for me to be focusing on at this stage of my care?
4This trial has no assigned phase, which often means it's exploring a new combination rather than testing a drug — does that affect the level of evidence we'd expect to come out of it, and how should I weigh that when deciding whether it's worth considering?
5Are there standard or already-established cystic fibrosis airway clearance protocols that might address my cough and exercise tolerance right now, rather than waiting for this study to open?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Cough Severity
Timeframe: Baseline and after 8 weeks of intervention
2
Change in Exercise Tolerance
Timeframe: Baseline and after 8 weeks of intervention