Nanozymes in Endodontics (NCT07518901) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Nanozymes in Endodontics
United States72 participantsStarted 2026-06
Plain-language summary
The antimicrobial efficacy and healing potential of clinically approved ferumoxytol nanozymes versus the standard 3% NaOCl irrigant will be evaluated in adults undergoing endodontic treatment. Building on prior protocols that demonstrated ferumoxytol nanozymes antimicrobial activity as a root canal irrigant, ferumoxytol solution will be applied topically, assessment of clinical and radiographical findings will determine its potential as a novel disinfection and its long-term outcome.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patients willing to participate in the study.
✓. Patients are 18 years or above.
✓. Non-contributory medical history (Patient can be seen for regular dental appointment in PDM; ASA classes I and II).
✓. Tooth requiring root canal treatment with radiographic presence of periapical radiolucency and
✓. responding to thermal sensitivity testing negatively (Difluordichlormethane at 50 °C, Endo-Ice,
✓. Coltène/Whaledent Inc., Cuyahoga Falls, Ohio) or a negative response to EPT testing.
✓. Tooth with adequate remaining tooth structure for proper isolation with rubber dam.
✓. No history of previous endodontic treatment on the tooth.
Exclusion criteria
✕. Self-reported pregnancy.
✕. Patients requiring antibiotic premedication prior to dental treatment.
✕. Patients with multiple drug allergies.
✕. Patients with known hypersensitivity to Ferumoxytol nanoparticles or any iron products.
✕. Patients who are scheduled for MRI for the head region within three months after Ferumoxytol nanoparticles application.
What they're measuring
1
The change in bacterial count between the experimental group (Ferumoxytol/H2O2) and the standard of care (NaOCl) group.