Assessing the Effect of an Aerobic Exercise Program on Vascular Function in Women With Non-Metast… (NCT07517224) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Assessing the Effect of an Aerobic Exercise Program on Vascular Function in Women With Non-Metastatic Breast Cancer
40 participantsStarted 2026-05-01
Plain-language summary
The goal of this clinical trial is to assess the feasibility of an 8-week aerobic exercise program and its effect on arterial function in breast cancer survivors.
The main questions it aims to answer are:
* Is an 8-week aerobic exercise program feasible in breast cancer survivors after the completion of chemotherapy?
* Is this 8-week aerobic exercise program beneficial for vascular function in breast cancer survivors?
Participants will:
* Begin an 8-week aerobic exercise program, three days per week, after the completion of chemotherapy.
* Visit our facility three times before the exercise program, 1 month after, and after the completion of the program.
* Complete questionnaires, physical functional tests, and body composition and vascular measurements at every visit.
Who can participate
Age range18 Years
SexFEMALE
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Inclusion criteria
✓. Women (18+ years) with a stage I-III breast cancer diagnosis who have completed chemotherapies.
✓. Completed the final chemotherapy cycle within the past 4 weeks.
✓. Sedentary by self-reporting inactivity (\<90 min of moderate or vigorous exercise per week)
✓. Body mass index ≤40 kg/m²
✓. Willing to complete all study activities
✓. Able to safely participate in moderate aerobic exercise.
Exclusion criteria
✕. Current pregnant and lactating patients. Must have completed lactation prior to study start.
✕. Metastatic disease.
✕. Diagnosed cardiovascular disease prior to the initiation of chemotherapy, as evidenced by cardiomyopathy (reduced regional or global left ventricular contractility), diastolic dysfunction grade 2 or above, symptomatic coronary artery disease, ejection fraction below 50%.
What they're measuring
1
Enrollment (Recruitment rate)
Timeframe: From enrollment to immediately after first visit
2
Participant adherence - Proportion of people considered adherent
Timeframe: From enrollment to the end of intervention at 8 weeks
3
Retention - Proportion of survivors who completed the study
Timeframe: From enrollment to the end of intervention at 8 weeks
4
Pulse Wave Velocity
Timeframe: From enrollment to the end of intervention at 8 weeks"
5
Aortic Blood Pressure
Timeframe: From enrollment to the end of intervention at 8 weeks