Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache (NCT07515456) | Clinical Trial Compass
RecruitingNot Applicable
Theophylline, Versus Sumatriptan and Gabapentin in The Treatment of Post-Dural Puncture Headache
Egypt75 participantsStarted 2024-12-01
Plain-language summary
The aim of this study is to compare the safety and efficacy of theophylline, sumatriptan, and gabapentin in the treatment of post-dural puncture headache.
Who can participate
Age range21 Years – 50 Years
SexALL
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Inclusion Criteria:
* Age from 21 to 50 years.
* Both sexes.
* American Society of Anesthesiologists (ASA) physical status ≤ II.
* Patient's selection for this study will be based on clinical diagnosis suggesting post-dural puncture headache (PDPH) based on the International Headache Society criteria.
* Patients with numeric rating scale (NRS) of ≥ 5.
Exclusion Criteria:
* Pregnant women.
* History of; chronic headache, cluster headache, migraine, convulsions, cerebrovascular accident, and previous neurological diseases.
* Signs of meningismus.
* Dysrhythmia.
* Hypertension.
* Ischemic heart disease.
* Hyperthyroidism.
* Peripheral vascular disease (ischemic colitis).
* Liver or renal impairment.
* Use of selective serotonin reuptake inhibitors.
* Use of ergotamine derivatives in the past 24 hours.
* Use of monoamine oxidase inhibitors in the last 2 weeks.
* Use of any kind of opiates.
* Allergy to the study medications and any contraindication of oral intake.