CRIC Combined With MFT for MFR in Patients With Incomplete Revascularization of CAD (NCT07514624) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
CRIC Combined With MFT for MFR in Patients With Incomplete Revascularization of CAD
480 participantsStarted 2026-05-01
Plain-language summary
The main objective of this study is to demonstrate whether the combination of chronic remote ischemic conditioning and mindfulness therapy can improve myocardial flow reserve in patients with incomplete revascularization of coronary artery disease.
Who can participate
Age range18 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age ≥18 years old
* Consistent with the diagnosis of coronary heart disease, complete revascularization was not performed (coronary angiography showed that at least one vessel with a reference diameter of 3.0mm had stenosis greater than 90%, and quantitative flow ratio (QFR) \< 0.80)
* Symptoms of myocardial ischemia (resting or exertional angina; Angina allele: chest tightness, shortness of breath, etc.);
Exclusion Criteria:
* • Age \< 18 years old
* Heart failure patients with NYHA class IV, or left ventricular ejection fraction (LVEF) \< 30%
* Creatinine clearance \<15 mL/min (or eGFR \< 15 mL/min/1.73m²), or requires dialysis
* Myocardial diseases such as hypertrophic cardiomyopathy, dilated cardiomyopathy, etc.
* Uncontrolled or recurrent arrhythmic events (e.g., ventricular fibrillation, recurrent or symptomatic sustained ventricular tachycardia, complete heart block, atrial fibrillation with rapid ventricular rates, supraventricular tachycardia refractory to drugs)
* Poorly controlled hypertension (SBP \> 180 mm Hg or DBP \> 110 mm Hg)
* Active liver disease or persistent ALT or AST elevation ≥ 3 times the upper limit of normal
* Unexplained CK \> 5 times the upper limit of normal, or elevated CK due to known muscle disease
* Planned or anticipated cardiac surgery or revascularization before randomization
* History of active malignancy (surgery, radiation therapy, and/or systemic therapy within the past 3 years)
* Diagnosed…
What they're measuring
1
Change in Myocardial Flow Reserve (MFR)
Timeframe: 6 months
Trial details
NCT IDNCT07514624
SponsorHenan Institute of Cardiovascular Epidemiology