RecruitingNot Applicable

Investigation of the Effectiveness of Exercise and Anti-Fibrotic Approaches in Frozen Shoulder

Turkey (Türkiye)33 participantsStarted 2026-01-07

Plain-language summary

The purpose of this clinical study is to investigate the efficacy of losartan as an antifibrotic approach in addition to a physiotherapy program in patients diagnosed with frozen shoulder. The effects of losartan use on pain intensity, shoulder joint range of motion, functional status, and pain catastrophizing level will be evaluated and compared with the outcomes of patients participating in a physiotherapy program alone. The key questions this study aims to answer are: * Is there a difference in shoulder functionality between frozen shoulder patients using losartan in addition to a physiotherapy program and those participating in a physiotherapy program alone? * Is there a difference in pain intensity, shoulder joint range of motion, and pain catastrophizing level between frozen shoulder patients using losartan in addition to a physiotherapy program and those participating in a physiotherapy program alone? A total of 33 patients will be enrolled in the study. Participants will be randomly assigned to one of two groups: the physiotherapy group (PT) and the physiotherapy + losartan group (PT+L). Both groups will receive the same physiotherapy program comprising range of motion exercises, stretching exercises, strengthening exercises, and mobilization techniques. Patients in the PT+L group will additionally receive 12.5 mg of oral losartan once daily for four weeks. Clinical assessments will be conducted at baseline, at week 4, and at week 8.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18 years or older diagnosed with frozen shoulder (adhesive capsulitis) * Having less than 50% of range of motion (ROM) in at least one of the following shoulder movements compared to the unaffected side: external rotation, abduction, flexion, or internal rotation * Having more than 25% loss of ROM in at least two movement planes compared to the unaffected shoulder * Patients in stage II or III of frozen shoulder Exclusion Criteria: * Women who are pregnant, breastfeeding, or planning pregnancy during the study * Patients in stage I of frozen shoulder * Patients diagnosed with inflammatory or other types of arthritis due to autoimmune diseases affecting the shoulder * Patients with rotator cuff pathology and/or glenohumeral arthritis * Patients with a history of prior shoulder infection * Patients with hypotension * Patients who have undergone previous upper extremity surgery or plan to undergo upper extremity surgery during the study period * Patients with allergy to losartan or its active/inactive components * Patients taking medications known to have adverse interactions with losartan * Patients who, in the investigator's opinion, have any medical condition, laboratory abnormality, or history that could pose risk, contraindicate participation, affect the conduct, objectives, or evaluation of the study, or prevent full participation in the study

What they're measuring

Quick Disabilities of the Arm, Shoulder and Hand Questionnaire (QuickDASH)

Timeframe: At baseline, at week 4, and at week 8

Trial details

NCT IDNCT07513350

SponsorIstanbul University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-11

Contact for this trial

Ayşe Betül Erol, Bachelor's degree

+90 534 669 14 06 aysebetul.yildiz@ogr.iuc.edu.tr