The goal of this clinical trial is to evaluate the safety, tolerability, immunogenicity and Pharmacokinetics (PK) characteristics of AHB-171 Injection in healthy participants (Part A) and participants with chronic hepatitis B (CHB, Part B), and assess its preliminary efficacy in CHB participants.
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Part A & Part B Incidence and severity of Treatment-Emergent Adverse Events (TEAEs) and Serious Adverse Events (SAEs); proportion of participants with clinically significant abnormal laboratory tests, electrocardiograms (ECGs), physical examinations, and
Timeframe: PartA:Up to 16 weeks, PartB: Up to 48 weeks
Part A:Plasma Cmax of AHB-171
Timeframe: Up to Day 8
Part A:Plasma Tmax of AHB-171
Timeframe: Up to Day 8
Part A Plasma AUC of AHB-171
Timeframe: Up to Day 8
Part A Plasma t1/2 of AHB-171
Timeframe: Up to Day 8