Transcranial Photobiomodulation for Bipolar Depression

Inclusion Criteria: * • Diagnosis of bipolar depression * Montgomery-Asberg Depression Rating Scale (MADRS) of 24 or higher * Capable of providing consent * Currently inpatient or outpatient * Ability to communicate in spoken and written English fluently enough to complete the required study assessments Exclusion Criteria: * Currently in manic or mixed episode, as measured by Young Mania Rating Scale (YMRS) more than 8-10 * Currently psychotic * Judged to be at serious and imminent suicidal risk * Currently has alcohol or substance use disorder (meeting criteria in the past 1 months) * Unstable medical conditions * Inability to consent or to complete study procedures * Changes in medications or use of augmentative devices and other interventions in the 4 weeks prior to the study * Participation in other clinical research trials that may influence primary outcomes or adherence to the proposed study * Current pregnancy or intention to become pregnant