Cerebellar Research in Ultrasound Stimulation (NCT07508696) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Cerebellar Research in Ultrasound Stimulation
Belgium60 participantsStarted 2026-06-01
Plain-language summary
Experiment 1: Modulation of Physiological Tremor in Healthy Volunteers Thirty healthy volunteers will undergo TUS targeting the dentate nucleus in a randomized, double-blinded crossover design. Tremor amplitude, induced by a 15 g weight, will be measured using an accelerometer, and EEG will assess neural oscillations and cerebello-thalamo-cortical connectivity.
Stimulation will include short-term (1 minute on/off for 12 minutes) and long-term (30 minutes) protocols, as well as closed-loop TUS for phase-specific effects. This experiment aims to optimize stimulation parameters and explore the dentate nucleus's role in tremor generation.
Experiment 2: Tremor Modulation in Essential Tremor Patients Thirty ET patients will receive TUS targeting the dentate nucleus with optimized parameters from Experiment 1 in a randomized crossover design. The best protocol from previous experiment will be tested here. Tremor amplitude and EEG will be recorded to assess short- and long-term effects of TUS on pathological tremor.
Who can participate
Age range18 Years – 75 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
✓. Participants aged 18-55 years
✓. Male of female
✓. Good health with no history of serious mental illness or implanted metal
✓. Willingness to adhere to the TUS and MRI study schedule
✓. Willingness to avoid caffeine and alcohol intake for at least 2 h prior to the investigation
✓. Voluntary written informed consent of the participant or their legally authorized representative has been obtained prior to any screening procedures
✓. Participants aged 18-75 years
Exclusion criteria
✕. Currently taking any psychotropic medication
✕. Any head trauma resulting in loss of consciousness
What they're measuring
1
Tremor amplitude
Timeframe: Experiment 1 (short-term effects): 1-minute recording segments up to 10 minutes after stimulation, Experiment 1(long-term effects): Up to 30 minutes after stimulation Experiment 2 (Essential tremor): Up to 30 minutes after stimulation
2
Tremor frequency
Timeframe: Experiment 1 (short-term effects): 1-minute recording segments up to 10 minutes after stimulation, Experiment 1 (long-term effects): Up to 30 minutes after stimulation Experiment 2 (Essential tremor): Up to 30 minutes after stimulation