RecruitingPhase 1/2

Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing

Egypt40 participantsStarted 2026-01-15

Plain-language summary

This study evaluates two different treatments used to help the jawbone heal after a tooth is removed. When a tooth is extracted, the surrounding bone often shrinks, which can make it difficult to place dental implants later. Currently, doctors often use Platelet-Rich Fibrin (PRF), which is made from the patient's own blood, to help the area heal. This research compares PRF to a newer treatment using "exosomes" derived from stem cells. Exosomes are tiny particles that carry signals to tell the body to repair tissue and grow new bone. The goal of this study is to see if these exosomes work better than PRF at keeping the bone strong and thick after an extraction. Researchers will use specialized X-rays (CBCT) to measure the bone three months after the procedure to see which treatment provided better results.

Who can participate

Age range20 Years – 45 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Patients aged between 20 and 45 years. * Patients requiring a single tooth extraction of a non-infected tooth in the aesthetic zone (incisors, canines) or premolar area. * Presence of adjacent teeth to the extraction site. * Adequate oral hygiene (Plaque Index \< 20%). * Patients willing and able to comply with the follow-up schedule and 3-month CBCT scan. * Signed informed consent provided by the participant. Exclusion Criteria: * Patients with systemic diseases that contraindicate oral surgery or interfere with bone healing (e.g., uncontrolled diabetes, osteoporosis, hyperparathyroidism). * History of head and neck radiation therapy or bisphosphonate medication use. * Active infection or acute abscess at the extraction site. * Heavy smokers (more than 10 cigarettes per day). * Pregnant or lactating women. * Patients with poor oral hygiene or active periodontal disease in the rest of the mouth. * Use of any medications known to affect bone metabolism (e.g., long-term corticosteroids).

What they're measuring

Change in Alveolar Bone Density (Hounsfield Units)

Timeframe: Baseline (Day of surgery) and 3 months post-operatively.

Trial details

NCT IDNCT07508033

SponsorAl Salam University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-07-15

Contact for this trial

Omaima M Sakr, BDS, MSc, PhD

+201001051538 drsakr2009@hotmail.com