Comparison of the Effects of Oral Hygiene Regimens on Clinical, Immunomodulatory, and Microbial Outcomes and Oral Tolerance in People With Gingivitis

Exclusion criteria

• ✕. Significant oral soft tissue pathology or active dental caries, based on the dentist's visual examination and at the discretion of the Investigator.
• ✕. History of significant adverse reactions, including sensitivity or suspected allergies, following use of oral hygiene products such as toothpastes, mouth rinses, and red food dye.
• ✕. Periodontitis, as determined by more than 2 sites with a probing depth greater than 4mm.
• ✕. Regular consumption of probiotics supplements within one week prior to screening. Subjects can be rescreened if they fulfill this criterion.
• ✕. Dental prophylaxis within 4 weeks prior to screening. Subjects can be rescreened if they fulfill this criterion.
• ✕. Subjects who wear orthodontic bands, fixed retainers, removable orthodontic appliances, clear aligners or night guards or subjects who have had significant (based on the examiner or PI's oral exam) cosmetic restorations.
• ✕. History of medical conditions requiring prophylactic antibiotic coverage prior to dental procedures.
• ✕. Self-reported tobacco, cannabis, smokeless tobacco use, including snuff, chewing tobacco, vaping, and e-cigarette usage.