The purpose of this study is to assess the feasibility, safety and efficacy of H3K27M-specific engineered immune effector (EIE) therapy in patients with high-risk, H3K27M-positive diffuse midline glioma/diffuse intrinsic pontine glioma. Another goal of the study is to learn more about the function of the anti-H3K27M EIE cells and their persistency in patients.
Who can participate
Age range2 Years – 70 Years
SexALL
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Inclusion criteria
✓. Abilities to understand and the willingness to provide written informed consent;
✓. ≥ 2 and ≤ 70 years old;
✓. Recurrent or refractory diffuse midline glioma or diffuse intrinsic pontine glioma patients with confirmed H3K27M mutation and documented lesions. Patients have received standard care of medication, such as gross total resection with concurrent radio-chemotherapy (\~54 - 60 Gy, TMZ). Patients must either not be receiving dexamethasone or receiving ≤ 4 mg/day at the time of leukopheresis;
✓. Karnofsky performance score (KPS) ≥ 60;
✓. Life expectancy \>3 months;
✓. Satisfactory bone marrow, liver and kidney functions as defined by the following: absolute neutrophile count ≥ 1500/mm\^3; hemoglobin \> 10 g/dL; platelets \> 100000 /mm\^3; Bilirubin \< 1.5×ULN; alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \< 2.5×ULN; creatinine \< 1.5×ULN;
✓. Peripheral blood absolute lymphocyte count must be above 0.8×10\^9/L;
✓. Satisfactory heart functions;
Exclusion criteria
✕. A prior history of gliadel implantation 4 weeks before this study start or currently receiving antibody based therapies;
✕. HIV positive;
✕. Tuberculosis infection not under control;
What they're measuring
1
Percentage of adverse effects after H3K27M-EIE injection
. History of autoimmune disease, or other diseases require long-term administration of steroids or immunosuppressive therapies;
✕. History of allergic disease, or allergy to immune cells or study product;
✕. Patients already actively enrolled in other immune cell clinical study; Patients, in the opinion of investigators, may not be eligible or not able to comply with the study.