Prophylactic Antibiotics for Outpatient Urethral Bulking
United States150 participantsStarted 2026-06
Plain-language summary
The purpose of this study is to evaluate whether taking prophylactic (preventative) antibiotics at the time of standard of care clinic-based urethral bulking reduces the risk of post-procedural urinary tract infection (UTI).
Who can participate
Age range18 Years
SexFEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Women ā„ 18 years of age.
* Patients evaluated by a pelvic floor specialist (either urogynecologist or urologist) at the University of Miami with plans to undergo urethral bulking with Bulkamid for stress urinary incontinence or mixed urinary incontinence (stress predominant).
* Negative testing for UTI in pre-procedural work-up (including either negative urine culture or urine dip negative for infection).
* Post-void residual volume of 150 mL or less (measured by either catheterization or bladder scan)
* Fluent in English or Spanish
* Able and willing to provide informed consent
Exclusion Criteria:
* Contraindications to both oral antibiotics including antibiotic allergies or significant renal disease (GFR \<30)
* Patient undergoing additional pelvic organ prolapse procedures or other urologic procedures concomitantly
* Recurrent UTIs, defined as 3 or more UTIs within the past 12 months or 2 UTIs within the past 6 months
* Patients currently taking daily antibiotic prophylaxis for any reason
* Pelvic organ prolapse stage greater than 2
* Patients with immunosuppression due to underlying medical conditions
* Patients who are pregnant
* Recent antibiotic treatment within one week of the procedure
* Unable or unwilling to provide informed consent or complete study procedures
What they're measuring
1
Incidence of post-procedural urinary tract infection (UTI) within six weeks following urethral bulking procedure