This randomised crossover study's primary aim is to investigate the effect of short-term fasting (eTRE) on subjective appetite and appetite-regulatory hormones (i.e., leptin, adiponectin, total glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), total peptide YY (PYY), acylated ghrelin and Insulin). In addition, to examine if the one-day early time-restricted eating influences energy expenditure and ad libitum energy intake in the periods following the standard meal test. The researchers will compare normal eating with early Time-Restricted Eating (eTRE) in healthy men.
Age range
18 Years – 65 Years
Sex
MALE
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The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Total Peptide-YY (PYY)
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Acylated Ghrelin
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Glucagon-Like Peptide-1 (GLP-1)
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Leptin
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Adiponectin
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Gastric inhibitory polypeptide (GIP)
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in Insulin
Timeframe: At 0 (fast baseline), 0.5, 1, 2, and 3 hours after standardised breakfast.
Change in subjective appetite sensations
Timeframe: Will take place seven times over a two-hour period in Day1 and nine times in Day2 at 0 (baseline), 0.5, 1, 2, 3, 4, 5, 6 and 7 hours.