The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on At… (NCT07499531) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
The Effect of Pulse Field Ablation of Atrial Fibrillation Involving Posterior Wall Ablation on Atrial Mechancis Assessed by Cardiac Magnetic Resonance Imaging
39 participantsStarted 2026-04
Plain-language summary
Assessing the impact of a new atrial fibrillation (AF) catheter ablation energy on left atrial structure and function is of crucial importance.
The goal of this clinical trial is to assess the effect of pulsed-field ablation of atrial fibrillation on left atrial structure.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patient age ≥ 18
* Established diagnosis of persistent or paroxysmal atrial fibrillation with a I/IIa/IIb indication for catheter ablation (ESC 2020 guidelines)
* AF ablation procedure planned using pulsed-field ablation and including at least pulmonary vein isolation and posterior wall isolation
* Episode of AF documented by ECG within the last 12 months
* Patient able to give written informed consent
* If female of childbearing potential, have a negative serum pregnancy test and using effective contraception
* Be affiliated with a French social security system or entitled
Exclusion Criteria:
* Only pulmonary vein isolation is scheduled
* Atrial fibrillation present at ECG during the pre-ablation (V1a) visit
* Contraindication to oral anticoagulation
* Intracardiac thrombus
* Previous ablation in the left atrium
* Previous heart surgery
* Significant valvular heart disease defined as any moderate (grade 3) or severe (grade 4) mitral regurgitation, mitral stenosis, aortic regurgitation, aortic stenosis, tricuspid regurgitation, or tricuspid stenosis
* Contraindication to perform MRI or using the DOTAREM™ contrast product (pacemaker, defibrillator, foreign body or prosthesis, old generation heart valves, old generation ferromagnetic vascular surgical clips, percutaneous devices for endocranial aneurysms, neurosimulator, cochlear implants, automated injection device such as insulin pump, and more generally any non-removable electronic device, severe kid…
What they're measuring
1
Difference between baseline (pre-ablation) and post-ablation (4 months) in the amount of left atrial fibrosis such as quantified by 3D late gadolinium enhancement (g, %) (MRI measurement).
Timeframe: From baseline to 4 months post ablation