TILs Therapy for Multiple Primary Early-Stage NSCLC

Inclusion criteria

• . Age 18-75 years, male or female;
• . Imaging findings showing multiple pulmonary nodules persisting after one year of follow-up, clinically diagnosed as multiple lung cancers by two associate senior or higher-level radiologists, two associate senior or higher-level thoracic surgeons, and one associate senior or higher-level oncologist, with patients refusing continued observation;
• . Patients with a history of surgical resection and pathological diagnosis of NSCLC, who subsequently show disease progression on imaging (progression of primary lesion or new nodules) during follow-up or after targeted therapy, diagnosed as lung cancer by a multidisciplinary expert team, and who refuse surgery or other treatments;
• . Ability to obtain a tumor sample of approximately 1-1.5 cm³ via surgery, biopsy, or bronchoscopy for preparation of autologous tumor-infiltrating lymphocytes;
• . ECOG performance status score of 0-2;
• . HGB ≥70 g/L, transfusion-eligible;
• . No severe hepatic, renal, cardiac, or pulmonary dysfunction, meeting the following criteria:
• . Estimated survival \> 5 years with complete clinical documentation.

Exclusion criteria