Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia … (NCT07494214) | Clinical Trial Compass
RecruitingPhase 1
Acute Analgesic Effects of MDMA on Experimentally Induced Acute Pain, Hyperalgesia and Allodynia in Healthy Participants
Switzerland20 participantsStarted 2026-03-09
Plain-language summary
This study investigates whether MDMA may have a pain-reducing effect. The effect of MDMA is compared with a placebo (a substance with no active effect).
In the study, moderate pain will be artificially created in healthy participants using repeated small electrical pulses applied under the skin. At the same time, participants will take MDMA or a placebo by mouth. This allows researchers to compare how MDMA affects the artificially created pain. A total of 20 healthy volunteers will take part in this study.
Who can participate
Age range18 Years – 75 Years
SexALL
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Inclusion criteria
✓. Age between 18 and 75 years old
✓. Sufficient understanding of the German language
✓. Understanding of procedures and risks associated with the study
✓. Willing to adhere to the protocol and signing of the consent form
✓. Willing to refrain from the consumption of illicit psychoactive substances during the study
✓. Willing not to operate heavy machinery for 48 hours after the study session.
✓. Willing to use effective birth control throughout study participation
✓. Body mass index between 18-34.9 kg/m2
Exclusion criteria
✕. Relevant chronic or acute medical condition
✕. Any implanted medical devices (e.g., pacemakers, neurostimulators, or metal prostheses)
✕. Current or previous major psychiatric disorder (e.g. bipolar disorder, schizophrenia), current depression or anxiety disorder.
✕. Psychotic disorder or bipolar disorder in first-degree relatives
✕. Hypertension (SBP\>140/90 mmHg) or hypotension (SBP\<85 mmHg)