By InvitationNot Applicable

Evaluation of Pain Thresholds in Migraine Patients After Inhalation of Essential Oils: a Randomized Clinical Trial

Brazil200 participantsStarted 2025-03-13

Plain-language summary

This study will test whether inhaling essential oils can change how sensitive people with migraine are to pressure pain. Participants will be allocated to inhale lavender, peppermint, a combination of both, or a control solution (distilled water with coconut oil). Each group will have 50 participants. The inhalation will last 15 minutes and will happen only once. Before and after the inhalation, we will measure how much pressure on certain areas of the head.

Who can participate

Age range18 Years – 60 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults aged 18-65 years * Diagnosis of episodic or chronic migraine according to the Internactional Classification of Headache Disorders (ICDH-3) * History of migraine for at least 1 year * Ability to understand and provide informed consent * Participants currently using or not using migraine preventive medication Exclusion Criteria: * Severe acute circulatory disorders * Diabetes melitus * Uncontrolled arterial hypertension * Fribromyagia * Anosmia or hyposmia * Known allergy or hypersensitivity to essential oils or their components * Pregnancy or breastfeeding

What they're measuring

Pain pressure threshold

Timeframe: Baseline (pre- inhalation) and immediately after inhalation (within 15 minutes)

Trial details

NCT IDNCT07493434

SponsorUniversity of Sao Paulo

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2027-03

View on ClinicalTrials.gov More Migraine trials