Not Yet RecruitingNot Applicable

A Behavioral Application for Improving Smoking Cessation Among Smokers

United States1,812 participantsStarted 2026-08-01

Plain-language summary

This clinical trial compares two smartphone applications, called Actify! (A \& B) for improving smoking cessation outcomes in individuals who smoke. Actify! A is an app grounded in behavioral activation therapy, an evidence-based treatment for depression that can also be used to modify health behaviors such as smoking. The Actify! B app provides evidence-based tobacco cessation strategies based on current clinical guidelines.

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age 18 or older * Currently smoke, averaging at least 5 cigarettes/day for the last 30 days * Interested in quitting smoking in the next 30 days * Experience downloading and using one or more apps on their smartphone * Either screens negative for depression (Patient Health Questionnaire - 9 item \[PHQ-9\] score 0-4; n = 906) or screens positive for mild to moderately severe current depressive symptoms (PHQ-9 score 5-19; n = 906) * Willing and able to complete all study activities and to receive compensation by mail * Comfortable reading and writing in English * Have a mobile data plan and/or access to WiFi to support the use of the assigned app * Reside in the United States (US) * Willing to provide information for an emergency contact in case of serious concerns about the participant's physical or mental health Exclusion Criteria: * Self-report of currently receiving behavioral treatment for depression (e.g., psychotherapy or counseling, web- or app-based interventions); current use of pharmacotherapy for depression or for other mental health conditions that are not otherwise excluded is allowable (e.g., benzodiazepines, anticonvulsants, opioid agonists, antipsychotics) * Severe depression (PHQ-9 ≥ 20) * Current suicidal ideation reported on the PHQ-9 * History of a suicide attempt * Self-reported lifetime diagnosis of bipolar disorder, schizophrenia, schizoaffective disorder, antisocial personality disorder, or borderline personality disorder; or se…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1This trial is still not yet recruiting — do you know when it might open, and should I be pursuing other smoking cessation options in the meantime rather than waiting?
2The main thing this trial is measuring is whether I've stopped smoking for 30 days based on what I self-report — how does my doctor feel about that as a measure, and does it align with what would actually matter for reducing my cancer risk?
3Since this is listed as a behavioral app-based intervention with no assigned phase, does that mean there's less certainty about how well it works compared to medications or counseling programs that already have more evidence behind them?
4Given that my diagnosis is tied to cigarette smoking-related carcinoma, is quitting through a study app the right priority right now, or would a more established, medically supervised cessation program be a better fit alongside my cancer treatment?
5Would my current health status, medications, or treatment plan for my cancer diagnosis affect whether I'd even be a good candidate to discuss for this kind of behavioral app trial?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Self-reported 30-day point prevalence abstinence (PPA) from cigarette smoking

Timeframe: At 6 months post-randomization

Trial details

NCT IDNCT07493252

SponsorFred Hutchinson Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2029-07-31

Contact for this trial

Jaimee Heffner, PhD

206-667-7314 jheffner@fredhutch.org

View on ClinicalTrials.gov More Cigarette Smoking-Related Carcinoma trials