APLAUD Trial (Antibiotics vs PLacebo for Acute Uncomplicated Diverticulitis)

Inclusion Criteria: * Patients presenting to the emergency department with left-sided uncomplicated diverticulitis * Radiologic score (moderate diverticulitis per Ambrosetti classification) * Age 18-90 * Access to a smartphone with internet access. Exclusion Criteria: * Complicated diverticulitis (abscess, free air, peritonitis)- severe diverticulitis by Ambrosetti classification * Diverticulitis other than left colon * Contraindication to use of study medication (ie advanced renal failure or allergy to all antibiotics used in the study) * Concurrent cancer diagnosis * Concurrent IBD Diagnosis * Any other disease process with life expectancy \< 6 months * Concurrent chronic pain diagnosis. * Women in pregnancy or breastfeeding * Antibiotic treatment for any reason in the last 3 weeks * Diagnosis of prior episode of acute diverticulitis in the past 3 months * Significant comorbidities: diabetes mellitus with organic involvement (retinopathy, angiopathy, nephropathy), emergency assistance for a cardiogenic event in the last 3 months (acute myocardial infarction, angina, heart failure), decompensation of chronic liver disease in the last 3 months (Child ≥ B) and end-stage renal disease. * Immunodepression: the absence, and immunodepression is the presence, of any of the following: active neoplastic disease, hematologic malignancy, human immunodeficiency virus long-term corticosteroid treatment, immunosuppressant therapy (20mg pred (or equivalent) for \>2 weeks), transplant, s…