GS1-144 in Participants With Hepatic Impairment and Healthy Female

Inclusion criteria

• ✓. Hepatic impairment caused by hepatitis B, hepatitis C, autoimmune hepatitis, nonalcoholic fatty liver disease, alcoholic liver disease, etc., with Child-Pugh classification assessed as Class A/mild (Child-Pugh score: 5-6) or Class B/moderate (Child-Pugh score: 7-9)
• ✓. A stable medication regimen for the treatment of hepatic impairment, complications, and/or other concomitant diseases for at least 14 days prior to screening, with no need for modification (e.g., medication type, dose, or dosing frequency); or not receiving medication.
• ✓. Clinical laboratory tests: absolute neutrophil count (ANC) ≥ 1.0 × 109/L (1,000/mm3), platelets (PLT) ≥ 35.0 × 109/L (35,000/mm3), hemoglobin (HGB) ≥ 8.0 g/dL (80 g/L), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 5 times the upper limit of normal (ULN), creatinine clearance (CLcr, calculated using the Cockcroft-Gault formula) ≥ 60 mL/min.
• ✓. Systolic blood pressure 90-159 mmHg (Inclusive), diastolic blood pressure 60-99 mmHg (inclusive), and pulse rate 50-100 beats per minute (bpm, inclusive).