Arthrosamid vs. Steroid for the Management of Knee Osteoarthritis

Inclusion Criteria: * Adults * Symptomatic single side knee pain. * Patients with diagnosis of knee osteoarthritis radiographic Kellgren and Lawrence system OA grade II-III-IV on x ray or MRI. Exclusion Criteria: * Inflammatory conditions, * Cancer, * acute infection, * pregnancy and breastfeeding. * Uncontrolled diabetes mellitus, * Joint diseases in the knee, such as rheumatoid arthritis or gout, history of knee surgery with metallic implant. * If patient has undergone knee arthroscopy in past 6 months. * Intra-articular injection of corticosteroids during the previous 3 months, intra-articular injection of other drugs, such as hyaluronic acid over the previous 1 year. * Contraindications for intra-articular injection, such as thrombocytopenia, coagulopathy, articular infection of knee, impairment of immunity.