Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reprodu… (NCT07488949) | Clinical Trial Compass
RecruitingNot Applicable
Doxycycline and Progestin Therapy for Chronic Endometritis(CE) in Patients With Recurrent Reproductive Failure(RRF)
China1,000 participantsStarted 2024-04-09
Plain-language summary
A Prospective Randomized Controlled Trial, the goal of this clinical trial is to evaluate the efficacy and safety of doxycycline alone versus doxycycline plus medroxyprogesterone acetate (MPA) in women with chronic endometritis (CE), and to assess subsequent reproductive outcomes. Participants will be randomly assigned to one of two groups and will receive the assigned treatment. Participants will be followed for reproductive outcomes, including pregnancy , ongoing pregnancy, spontaneous miscarriage, and live birth.
Who can participate
Age range
20 Years – 45 Years
Sex
FEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* women aged 20-45 years;
* plans to conceive within 12 months;
* chronic endometritis(CE) confirmed by endometrial CD138 immunohistochemistry (IHC);
* a diagnosis of recurrent reproductive failure(RRF);
* willingness to undergo hysteroscopy and endometrial biopsy;
* no contraindications to the study medications.
Exclusion Criteria:
* acute genital tract infection, gynecologic malignancy, endometrial hyperplasia, or uterine fibroids;
* pregnancy or lactation;
* contraindications to hysteroscopy or anesthesia;
* use of antibiotics, glucocorticoids, estrogens, or progestins within 3 months before trial initiation;
* allergy to doxycycline or medroxyprogesterone acetate(MPA);
* abnormal semen parameters in the male partner.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Cure rate of chronic endometritis
Timeframe: At 8 weeks after completion of treatment