Effect of Acupuncture on the Success Rate in Patients With Recurrent Implantation Failure (NCT07486297) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Effect of Acupuncture on the Success Rate in Patients With Recurrent Implantation Failure
China208 participantsStarted 2026-03-01
Plain-language summary
To conduct a multi-center, randomized, controlled clinical study aimed at formally evaluating the impact of pressing therapy on the success rate in patients with recurrent implantation failure.
Who can participate
Age range20 Years – 40 Years
SexFEMALE
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Inclusion criteria
✓. Meets the criteria for RIF diagnosis (≥ 2 instances of unsuccessful transfer of high-quality embryos).
✓. Age: 20 to 40 years old.
✓. Planning for a cycle involving the transfer of frozen-thawed embryos (FET).
✓. Possession of a transplantable D3 frozen embryo (≥6 cells) or a frozen blastocyst (≥3BC).
✓. Estradiol-progesterone replacement therapy: endometrial thickness ≥ 7 mm within the period of endometrial transformation.
Exclusion criteria
✕. Individuals planning to undergo preimplantation genetic diagnosis (PGD).
✕. Recipients of egg donations.
✕. Chromosomal abnormalities in either spouse or one partner (excluding chromosomal polymorphisms).
✕. Patients with known embryo-related factors leading to implantation failure.
✕. Abnormalities of the uterus that may affect implantation (including uterine malformations, uterine tuberculosis, submucosal myomas, severe uterine adhesions, severe uterine endometriosis, myomas with a diameter of ≥4 cm, and so on).
✕. Recurrent spontaneous abortions (loss of a fetus before 28 weeks of gestation occurring twice or more).
✕. Individuals with other endocrine disorders, such as thyroid disorders, hyperprolactinemia, insulin resistance, diabetes, and adrenal disorders, whose hormone levels have not been well-controlled over the past 3 months.
What they're measuring
1
clinical pregnancy
Timeframe: 1 year
Trial details
NCT IDNCT07486297
SponsorHuazhong University of Science and Technology