By InvitationNot Applicable

Ultrasound Elastography of Carpal Tunnel Syndrome

Vietnam80 participantsStarted 2025-04-15

Plain-language summary

Carpal Tunnel Syndrome (CTS) is the most common peripheral nerve compression disorder in adults. Although electromyography (EMG) is the current gold standard for diagnosis, it is invasive, time-consuming, and may yield false-negative results. Ultrasound elastography, including shear wave elastography and strain elastography, enables non-invasive assessment of median nerve stiffness, reflecting fibrosis and edema. However, data on the combined use of elastography and microvascular imaging in CTS are still limited in Vietnam. This study aims to evaluate the value of advanced ultrasound techniques in diagnosing CTS and grading disease severity, as well as their correlation with clinical symptoms and EMG findings

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion Criteria (Case Group) * Patients \>18 years old. * Clinical suspicion of CTS with at least one sign: numbness/pain in the median nerve distribution (digits 1, 2, 3, and lateral 4), nocturnal symptoms, or positive provocative tests (Tinel, Phalen, Durkan). * Confirmed diagnosis of CTS via Electrodiagnostic studies (NCS/EMG) based on American Academy of Neurology (AAN) and AANEM criteria. Inclusion Criteria (Control Group) * Healthy volunteers with no clinical symptoms of CTS. * Normal electrodiagnostic results. Exclusion Criteria: * Exclusion Criteria * History of prior CTS treatment (steroid injection, surgery). * Presence of cervical radiculopathy, polyneuropathy, or proximal median nerve entrapment. * Secondary causes of CTS identified on ultrasound (e.g., gouty tophi, ganglion cysts, tumors, tenosynovitis). * Anatomical variants such as a bifid median nerve or persistent median artery. * Refusal to participate in the study

What they're measuring

Diagnostic Accuracy of Shear Wave Elastography for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)

Diagnostic Accuracy of Strain Elastography (SE) for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)

Diagnostic Accuracy of Median Nerve Cross-Sectional Area (CSA) for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)

Trial details

NCT IDNCT07486284

SponsorDa Nang Family General Hospital

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-03-20

View on ClinicalTrials.gov More Carpal Tunnel Syndrome (CTS) trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

Diagnostic Accuracy of Shear Wave Elastography for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)

Diagnostic Accuracy of Strain Elastography (SE) for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)

Diagnostic Accuracy of Median Nerve Cross-Sectional Area (CSA) for Carpal Tunnel Syndrome

Timeframe: At baseline (data collected at the time of retinal examination during the study period from April 2025 to February 2026)