Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial (NCT07485569) | Clinical Trial Compass
Not Yet RecruitingPhase 1
Drug Repurposing in Thyroid Carcinoma: a Feasibility Trial
10 participantsStarted 2026-06-01
Plain-language summary
This is a phase Ib trial that studies personalized network pharmacology-based drug repurposing in patients with advanced thyroid cancer who have no other treatment options. The main objective is to study if it is feasible to give patients individualized drug combinations selected based on their tumor genetic profile. The secondary objective is to find out whether these treatments are safe and can help control the growth of the patient tumors or stop them from getting worse.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Patients with locally advanced or metastatic TC (such as ATC, PDTC, and RAI refractory DTC progressive under treatment with multikinase inhibitors) for whom no approved conventional treatments are available.
* Prior anticancer treatment-related toxicities resolved to Grade ≤1 (CTCAE v5.0).
* Measurable disease per RECIST 1.1
* ECOG performance status ≤ 2
* Negative pregnancy test within 7 days prior to starting the study in women of childbearing potential and adequate use of contraception.
Exclusion Criteria:
* Inability to provide informed consent
* Inability to obtain a (new) biopsy for molecular profiling
* Pregnancy or breastfeeding.
* Other active malignancies requiring therapy.
* Neutropenia (ANC \< 1.5 × 10⁹/L).
* Severe uncontrolled medical conditions (renal, cardiac, liver, respiratory).
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.