Aerobic Interval vs Continuous Training on Heart Rate-Power Decoupling in Ischemic Heart Disease (NCT07485400) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Aerobic Interval vs Continuous Training on Heart Rate-Power Decoupling in Ischemic Heart Disease
48 participantsStarted 2026-03-17
Plain-language summary
This study is a randomized, parallel-group clinical trial with assessor and statistical analyst blinding, conducted at a single center. Participants with stable ischemic heart disease enrolled in a cardiac rehabilitation program will be randomly allocated to one of two aerobic exercise interventions: long extensive continuous aerobic training (zone 2) or long extensive aerobic interval training (zone 3). Both groups will participate in supervised exercise sessions twice weekly for a period of 8 weeks, integrated into the standard cardiac rehabilitation program.
Assessments will be performed at baseline, immediately after the intervention period (8 weeks), and after a 4-week follow-up period without supervised training to evaluate potential detraining effects. The primary outcome is heart rate-power decoupling during a prolonged submaximal cycling exercise test, used as an indicator of cardiovascular efficiency. Secondary outcomes include heart rate response during submaximal exercise, exercise tolerance, heart rate recovery, blood pressure, functional capacity, quality of life, and adherence to the training program.
The objective of this study is to compare the effects of long extensive aerobic interval training versus long extensive continuous training on heart rate-power decoupling and related cardiovascular and functional outcomes in patients with ischemic heart disease undergoing cardiac rehabilitation.
Who can participate
Age range
40 Years – 75 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Confirmed diagnosis of cardiovascular disease requiring cardiac rehabilitation, with medical indication for a supervised exercise training program.
* Prognostic risk classified as low or moderate according to the clinical risk stratification established in the unit, considering:
* Killip class I or II (absence or mild heart failure)¹.
* Absence of recent acute myocardial infarction (\< 1 month) or presence of a stable previous infarction.
* Stable and well-controlled cardiovascular symptoms.
* Physical capacity demonstrated in functional tests ≥ 5 METs, preferably \> 7 METs for low-risk patients.
* Age between 40 and 75 years.
* Ability to perform physical exercise without absolute contraindications.
* Written informed consent and willingness to attend the scheduled sessions twice per week for 8 weeks.
Exclusion Criteria:
* High prognostic risk, defined by:
* Killip class \> III (moderate to severe heart failure).
* Recent acute myocardial infarction (\< 1 month) with clinical instability.
* Active anginal symptoms or decompensated heart failure.
* Physical capacity \< 5 METs on functional testing, indicating severely reduced exercise capacity.
* Presence of complex or unstable arrhythmias contraindicating vigorous physical exercise.
* Concomitant diseases that may limit participation or compromise safety (e.g., advanced pulmonary disease, severe renal failure, severe neuromuscular disorders).
* Absolute medical contraindications to …
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in heart rate-power slope during a submaximal incremental cycling test