A Bundled Intervention to End Opioid Overdoses (NCT07485335) | Clinical Trial Compass
Not Yet RecruitingPhase 4
A Bundled Intervention to End Opioid Overdoses
United States160 participantsStarted 2026-09-07
Plain-language summary
Opioid overdose deaths have reached historically high records in the United States and are particularly concentrated among patients after emergency department (ED) discharge. Evidence-based treatment modules to reduce repeat opioid overdose and mortality are lacking in this patient population. A bundled intervention is proposed, including telehealth, peer support specialist, buprenorphine, and linkage for definitive care, that is designed to increase treatment uptake in this patient population post-ED discharge, reduce repeat opioid overdoses, and end overdose deaths.
Who can participate
Age range19 Years
SexALL
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Inclusion criteria
✓. discharged from the ED and inpatient settings at the UAB hospital
✓. 19 years or older (the age of majority in Alabama);
✓. diagnosis of OUD and experiencing opioid overdose in the last 12 months;
✓. prescribed buprenorphine in the ED and willing to continue buprenorphine post-ED discharge;
✓. English speaking;
✓. not actively psychotic and suicidal, or cognitively impaired.
✓. Patients who are admitted to the hospital from the ED will be eligible for enrollment.
Exclusion criteria
✕. living in a restricted environment (e.g., prison or jail facility, etc.);
✕. currently enrolled in other clinical studies;
✕. anticipated to take other prescribed opioids except buprenorphine for a medical condition longer than three months;
What they're measuring
1
participant retention rate
Timeframe: 1 month and 3 months post hospital discharge
2
buprenorphine adherence rate
Timeframe: 1 month and 3 months post ED discharge
3
linkage rate to addiction treatment programs
Timeframe: 1 month and 3 months post hospital discharge
4
Frequency of Repeat Opioid Overdose
Timeframe: Monitored quarterly throughout the R33 study period beyond the 3-month intervention
5
Healthcare Utilization (Hospital Revisit Rates)
Timeframe: Monitored quarterly throughout the R33 study period beyond the 3-month intervention
6
Adherence to Peer Support Specialist Contact
Timeframe: Throughout the 12-week intervention period post hospital discharge
7
Opioid Overdose Death
Timeframe: Monitored quarterly throughout the R33 study period beyond the 3-month intervention