Safety and Immunogenicity of CVI-VZV-001 in Adults Aged 50 Years and Above

Inclusion Criteria: * Participants must meet all of the following criteria: * Healthy adults aged 50 years or older * Able to understand the study procedures and provide written informed consent * Females and males of reproductive potential must agree to use medically acceptable contraception until 3 months after the last vaccination * Females of childbearing potential must have a negative pregnancy test prior to vaccination Exclusion Criteria: * Participants meeting any of the following criteria will be excluded: * History of herpes zoster prior to screening * History of severe allergic reaction to vaccines or vaccine components * Known immunodeficiency or immune dysfunction * Prior vaccination with varicella or herpes zoster vaccine * Use of immunosuppressive therapy or systemic steroids that may affect immune response * Positive test for HCV, HBV, or HIV at screening * Pregnant or breastfeeding women * Any medical condition that, in the opinion of the investigator, would make participation unsafe or interfere with study evaluation