Fecal Microbiota Transplantation for Primary Sclerosing Cholangitis - Randomized Study Versus Sham Transplantation

Inclusion Criteria: * Males or females * Age ≥18 and ≤75 years * Large duct PSC verified by retrograde, operative, percutaneous or magnetic resonance cholangiography (MRC) demonstrating intrahepatic and /or extrahepatic biliary duct changes consistent with PSC * IBD diagnosed according to international guidelines (presence of endoscopic and histologic signs) * IBD inactive for at least 6 months (defined by no evidence of flare and no change in treatment) * ALP ≥ 1.3 ULN (at least 2 times within a 3 months pre-inclusion period) or elevated total bilirubin ≤50 umol/l (with concomitant elevated direct bilirubin). * Treatment with UDCA (13-23 mg/kg/d) for at least 6 months and at the same dosage for at least 3 months * Using contraceptive in women of childbearing potential and agrees to pursue it from inclusion until week 48. Women of childbearing potential, i.e. fertile, following menarche and until becoming post-menopaused unless permanently sterile, who are sexually active have to apply a highly effective method of birth control with a low failure rate (i.e. less than 1% per year) when used constantly and correctly. * Written informed consent signed * Subject affiliated to the French * Social Security System Exclusion Criteria: * Small duct PSC * Autoimmune hepatitis defined by the presence of moderate to severe interface hepatitis documented on liver biopsy and at least 1 of the 2 following criteria: AST or ALT \> 5 ULN, Positive anti smooth muscle auto antibodies or serum…