Active — Not RecruitingNot Applicable

Combination of Oral and Topical Whitening Agents for Reducing Skin Pigmentation

Malaysia68 participantsStarted 2024-12-01

Plain-language summary

The goal of this study is to evaluate the safety and efficacy of a combination use of oral supplement and topical serum in improving skin pigmentation in healthy women. The main questions it aims to answer are: Does combination use able to reduce the dark spot? Is there any adverse effect associate with the product use?

Who can participate

Age range

30 Years – 60 Years

Sex

FEMALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Healthy Malaysian women. * Aged 30 - 60 years old. * Fitzpatrick skin type III-V * Exhibiting signs of skin pigmentation such as post-inflammatory hyperpigmentation, freckles and solar lentigines. Exclusion Criteria: * Participants with melasma. * Pregnant, breastfeeding women, or those planning pregnancy during the study period. * Participants with documented chronic medical conditions such as kidney disease, diabetes, heart problems, liver disease, gastrointestinal disorders, and others. * Participants with documented autoimmune diseases. * Participants with inflammatory or allergic skin problems such as atopic dermatitis, rosacea, or psoriasis. * Use of topical agents for skin brightening within the past three months. * Consumption of food or supplement products containing L-glutathione, L-cysteine HCL monohydrate, polypodium leucotomos leaf extract, pine bark extract, or other similar supplements, as well as the use of topical products containing niacinamide, glycyrrhiza glabra (licorice) root extract, retinol, or other products for skin brightening or rejuvenation within three months prior to the study. * Undergoing any cosmetic procedures such as botox, laser and light treatment, facial surgery, or any procedures aimed at improving skin conditions (e.g., skin brightening, elasticity, wrinkles, pores) prior to the study. * Consumption of any medical or hormonal treatments that could interfere with the study results, such as isotretinoin, tranexam…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Skin spots assessment

Timeframe: Baseline, Week 6, Week 12

Skin brightening assessment

Timeframe: Baseline, Week 6, Week 12

Trial details

NCT IDNCT07477275

SponsorUSMARI Research & Innovation Centre

Sponsor typeINDUSTRY

Study typeINTERVENTIONAL

Primary completion2026-04-30

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