Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross… (NCT07474272) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Non-Surgical Treatment of Periodontitis With Adjunctive Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid
Lebanon78 participantsStarted 2026-03-11
Plain-language summary
The goal of this clinical trial is to learn if using sodium hypochlorite/amino acid gel, with or without cross-linked hyaluronic acid, as an addition to standard non-surgical periodontal therapy works to treat periodontitis in adults. It will also learn about the safety of these treatments. The main questions it aims to answer are:
Does the adjunctive treatment reduce bleeding on probing, plaque index, and periodontal pocket depth?
What medical or dental problems do participants have when receiving these treatments?
Researchers will compare:
Standard non-surgical periodontal therapy alone
Standard therapy plus sodium hypochlorite/amino acid gel
Standard therapy plus sodium hypochlorite/amino acid gel and cross-linked hyaluronic acid ("Clean and Seal" protocol)
Participants will:
Receive their assigned treatment during one clinical session per the study protocol
Have clinical measurements taken before treatment and at three months after treatment
Be monitored for any dental or medical adverse events related to the procedures
Who can participate
Age range
16 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Localized periodontal pocket with a probing depth ≥ 6 mm and a clinical - attachment loss of \> 3 mm (periodontitis stage III or IV; classification of the European Federation of Periodontology and American Academy of Periodontology);
* Patients who signed the written informed consent and is willing to cooperate;
* Bleeding on probing in more than 30% of the sites.
Exclusion Criteria:
* Medical history likely to affect periodontal status and/or to compromise treatment outcomes;
* Patients who received antibiotic and/or anti-inflammatory treatments the last 6 months
* Patients who received immunosuppressors treatments the last 6 months;
* Patients who received any periodontal therapy for the last 6 months;
* Pregnant or lactating women;
* Smokers smoking more than 10 cigarettes per day.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Probing Pocket Depth (PPD)
Timeframe: pre-operative and at 3 months post-operative