Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia

Inclusion criteria

• ✓. Community dwelling adults age 50 years and older (approximately equal numbers of men and women).
• ✓. Men should be sterile or agree to use contraception throughout the study.
• ✓. Women must be postmenopausal, defined as no menses in the last 5 years (to reduce variability in change in bone resorption since menopause prompts a rapid increase in bone resorption).
• ✓. Osteopenia will be defined as a bone mineral density (BMD) T-score at the lumbar spine, femoral neck, or total hip lower than -1 or higher than -2.5.
• ✓. On a prescreening interview, candidates must report a usual diet associated with an acid load by our validated short questionnaire.
• ✓. Estimated glomerular filtration rate (eGFR) must be 45 ml/min or greater.
• ✓. Participants must agree not to change their exercise pattern or medication use during the study.
• ✓. Participants must agree not to change their pattern of supplement use and not to use antacids during the study because most calcium supplements and other antacids add alkali.

Exclusion criteria