CompletedNot Applicable

AEROBIC ADAPTATION AND BIOMARKER RESPONSES IN COMBAT ATHLETES

Turkey (Türkiye)40 participantsStarted 2025-01-20

Plain-language summary

This randomized controlled study investigates the effects of sport-specific training on aerobic adaptation and circulating biomarker responses in trained combat athletes. Exercise induces systemic physiological adaptations through signaling molecules known as exerkines, including myokines and adipokines, which mediate communication between skeletal muscle and other metabolic organs. Forty trained male kickboxers are randomly assigned to either an experimental training group or a control group. The experimental group performs an eight-week sport-specific conditioning program in addition to regular technical training, while the control group maintains their usual training routine. Aerobic capacity is assessed using maximal oxygen uptake (VO₂max). Blood samples are collected before and after the intervention to determine circulating levels of exercise-responsive biomarkers, including myostatin, irisin, apelin, brain-derived neurotrophic factor (BDNF), fibroblast growth factor-21 (FGF21), and adiponectin. The primary objective of the study is to evaluate whether changes in circulating biomarker responses are associated with improvements in aerobic performance. The findings may provide insight into the molecular mechanisms underlying exercise-induced physiological adaptation in combat athletes.

Who can participate

Age range

18 Years – 25 Years

Sex

MALE

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male combat sport athletes aged between 18 and 25 years * Minimum five years of competitive kickboxing experience * Regular participation in training at least five days per week * Currently competing at the national level Exclusion Criteria: * Musculoskeletal injury within the previous six months * Cardiovascular or metabolic disease * Use of medications or supplements that may affect metabolic or hormonal responses * Participation in additional structured conditioning programs during the study period

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

VO₂max

Timeframe: Baseline and after 8 weeks

Trial details

NCT IDNCT07473440

SponsorAdiyaman University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-20

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