Glioblastoma (GBM) is the most common and most aggressive primary brain cancer in adults. GBM is more common in men than in women, with a male-to-female ratio of 1.6. Furthermore, being male is associated with a poorer prognosis. These data suggest that sex and/or sexual hormones and more specifically androgens may play a role in the initiation, the growth, and the resistance to treatments of GBM.
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Mean expression of AR, ER, and other hormone signaling pathway genes in the tumor
Timeframe: Baseline: Before any treatment; 4 to 6 weeks after completion of the concurrent radiochemotherapy