Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Th… (NCT07471282) | Clinical Trial Compass
Not Yet RecruitingPhase 3
Reperfusion Completion Via Local Arterial Infusion of Tenecteplase After Incomplete Mechanical Thrombectomy
China344 participantsStarted 2026-03-01
Plain-language summary
To evaluate the efficacy and safety of intra-arterial TNK bridging therapy following incomplete recanalization (2b ≤ eTICI \< 3) after mechanical thrombectomy for acute anterior circulation large vessel occlusion.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Age ≥ 18 years;
✓. Time from symptom onset or last known well to randomization within 24 hours;
✓. Clinical diagnosis of acute ischemic stroke caused by acute occlusion of the intracranial anterior circulation large vessels confirmed by CTA/MRA/DSA, including occlusion of the intracranial segment of the internal carotid artery, the M1 or M2 segments of the middle cerebral artery, with or without concomitant occlusion of the ipsilateral extracranial segment of the internal carotid artery;
✓. NIHSS score ≥ 6, and meeting the current guidelines for mechanical thrombectomy;
✓. Anterior circulation large vessel stroke due to occlusion of the intracranial ICA, MCA M1, or M2 segments;
✓. Pre-stroke mRS score ≤ 1;
✓. ASPECTS score ≥ 6;
✓. Post-mechanical thrombectomy status with 2b ≤ eTICI \< 3, and the operator has decided not to attempt further mechanical recanalization of the occluded vessel;
Exclusion criteria
✕. Contraindications to intravenous thrombolysis (excluding time-based criteria);
✕. DSA post-thrombectomy indicating dissection of the occluded artery, or intra-procedural flat-panel CT suggesting local hemorrhage or significant contrast extravasation;
✕. Baseline NIHSS score not obtained;
✕
What they're measuring
1
Excellent neurological outcome rate (mRS 0-1) at 90 (±7) days