Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis (NCT07470242) | Clinical Trial Compass
CompletedNot Applicable
Povidone-Iodine Nasal Irrigation After Surgery for Chronic Rhinosinusitis
South Korea48 participantsStarted 2021-10-13
Plain-language summary
This prospective randomized controlled trial evaluates the effectiveness and safety of different nasal irrigation solutions for postoperative care after endoscopic sinus surgery in patients with chronic rhinosinusitis. Patients undergoing endoscopic sinus surgery will be randomly assigned to receive nasal irrigation with normal saline, mucomyst, or diluted povidone-iodine solution for three months after surgery. Clinical outcomes, symptom scores, endoscopic findings, and potential ototoxic effects will be evaluated to compare the effectiveness and safety of these irrigation methods.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients diagnosed with chronic rhinosinusitis
* Patients who underwent endoscopic sinus surgery (ESS)
* Patients who performed postoperative nasal irrigation for 3 months
* Patients who completed the follow-up evaluation and agreed to participate in the study
Exclusion Criteria:
* History of chronic otitis media
* Presence of otitis media with effusion at the time of evaluation
* History of previous middle ear surgery
* Known allergy to povidone-iodine
* Incomplete follow-up data
* Refusal to participate in the study
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Lund-Kennedy Endoscopic Score
Timeframe: 3 months after endoscopic sinus surgery
2
Hearing function assessed by pure tone audiometry (PTA)
Timeframe: 3 months after endoscopic sinus surgery