Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies.
This prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age between 18 and 65 years
* ASA physical status I-II
* Scheduled for elective laparoscopic cholecystectomy
* Undergoing general anesthesia
* Ability to provide written informed consent
Exclusion Criteria:
* Patients younger than 18 years or older than 65 years
* Known allergy to dexamethasone
* ASA physical status III or higher
* Surgical procedures lasting longer than 120 minutes
* Emergency surgeries
* Pregnant or breastfeeding patients
* Patients with coagulopathy or receiving anticoagulant therapy
* Known allergy to local anesthetics
* Localized infection at the injection site
* Inflammatory bowel disease
* Autoimmune diseses
* Chronic pain conditions
* Ocular herpes simplex infection
* Cushing's disease
* Myasthenia gravis
* Anticipated poor compliance with the study protocol
* Vaccination within the last 14 days
* Use of systemic glucocorticoids or immunosuppressive drugs
* İmpaired renal function (GFR \< 30 mL/min)
* Liver cirrhosis
* Congestive heart failure
* Peripheral nerve disorders
* Elective laparoscopic cholecystectomy due to malignancy
* Conversion to open surgery during the operation
* Epilepsy
* Body mass index (BMI) \> 30 kg/m²
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.