Laparoscopic cholecystectomy is a commonly performed minimally invasive surgical procedure; however, postoperative pain, nausea, and delayed recovery remain clinically relevant problems. Glucocorticoids such as dexamethasone are widely used in perioperative care for the prevention of postoperative nausea and vomiting and as part of multimodal analgesia strategies. This prospective randomized controlled trial aims to compare the effects of moderate- and high-dose intravenous dexamethasone administered intraoperatively on postoperative recovery in patients undergoing elective laparoscopic cholecystectomy. The primary outcomes include postoperative nausea and vomiting, inflammatory markers (CRP and WBC), and Quality of Recovery-15 (QoR-15) scores. Secondary outcomes include postoperative pain scores, intraoperative remifentanil consumption, postoperative opioid consumption, and adverse events.
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Postoperative Nausea and Vomiting (PONV)
Timeframe: 30 minutes, 1 hour, 2 hours, 4 hours, 12 hours, and 18 hours postoperatively
CRP
Timeframe: preoperative and up to 18 hours postoperatively
Quality of Recovery (QoR-15 Score)
Timeframe: 18 hours after surgery
wbc
Timeframe: preoperative and up to 18 hours postoperatively