Trial of Tirzepatide for the Treatment of Cannabis Use Disorder (NCT07468552) | Clinical Trial Compass
Not Yet RecruitingPhase 2
Trial of Tirzepatide for the Treatment of Cannabis Use Disorder
100 participantsStarted 2026-11-15
Plain-language summary
The purpose of this randomized, double-blind, placebo-controlled, multi-site clinical trial is to evaluate the safety and efficacy of tirzepatide in a sample of 100 patients diagnosed with moderate or severe CUD by DSM-5 criteria.
Who can participate
Age range
18 Years – 70 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Between 18 and 70 years of age
* Meets DSM-5 criteria for moderate or severe CUD
* Interested in treatment for cannabis use disorder
* Able to understand the study procedures and written informed consent in English
* Willing to comply with all study procedures and medication instructions
* If female, is not pregnant, and agrees to use acceptable birth control methods
Exclusion Criteria:
* Body Mass Index (BMI) ≤ 23 kg/m²
* Presence of a medical or psychiatric disorder that contraindicates participation in the study
* Substance use disorder other than tobacco or mild alcohol-use disorder
* Known allergy or hypersensitivity to Tirzepatide, any GLP-1 or GIP receptor agonist, or any of the excipients in the product
* Current or recent (past 30 days) use of GLP-1 receptor agonists or other weight-loss drug
* Current or recent (past 6 months) enrollment in substance use disorder treatment
* Current or planned pregnancy and breastfeeding
* Living or medical situation that would interfere with adherence to the study protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.