The Impact of Dupilumab Treatment on Anxiety and Depression Symptoms in Patients With Moderate-to… (NCT07467564) | Clinical Trial Compass
RecruitingNot Applicable
The Impact of Dupilumab Treatment on Anxiety and Depression Symptoms in Patients With Moderate-to-Severe Atopic Dermatitis
Saudi Arabia, United Arab Emirates184 participantsStarted 2026-02-24
Plain-language summary
This study aims to assess the impact of dupilumab on the mental health and quality of life of moderate-to-severe Atopic Dermatitis (AD) patients. The study will recruit participants from AD patients who are already receiving dupilumab treatment. The study enrollment period will be about 9 months with each of the participants undergoing a 6-month observational study period.
Who can participate
Age range
12 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Participants who have moderate to severe AD with signs and symptoms of anxiety and/or depression.
* Participants who initiate dupilumab therapy within 30 days of enrolment, based on the treating physician's decision, independently of study participation
* Participants and/or their legally approved representatives (LAR in case of the minor subject) must agree to sign an informed consent or an assent.
Exclusion Criteria:
* Females who are pregnant, lactating, or planning/intending to be pregnant in the next 6 months.
* Participants who are participating in another trial.
* Participants with active chronic or acute infection requiring systemic treatment.
* Participants who are diagnosed with active endoparasite infection or are suspected of being at high risk of infection.
* Participants with human immunodeficiency virus (HIV), hepatitis B or C, malignancy, or other concomitant illnesses.
* Participants on antidepressants/anti-anxiety within 6 months of enrolment or those who are planning to receive antidepressants/anti-anxiety. In addition, those who will use antidepressants/anti-anxiety medications throughout the study will be excluded from the analysis.
The above information is not intended to contain all considerations relevant to a patient's potential participation in a clinical trial.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Proportion of Participants with Hospital Anxiety and Depression Scale Anxiety (HADS-A) Sub-scores of Less Than 8
Timeframe: Week 24
2
Proportion of Participants with HADS Depression (HADS-D) Sub-scores of less than 8
Timeframe: Week 24
3
Change from Baseline in HADS Total Score.
Timeframe: Baseline to up to Week 24
4
Proportion of Participants with More Than or Equal to 4-point Improvement in POEM Total Score
Timeframe: Week 24
5
Change from Baseline in POEM Total Score.
Timeframe: Baseline to up to Week 24
Trial details
NCT IDNCT07467564
SponsorSanofi
Sponsor typeINDUSTRY
Study typeOBSERVATIONAL
Primary completion2027-05-24
Contact for this trial
Trial Transparency email recommended (Toll free for US & Canada)