Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protect… (NCT07467213) | Clinical Trial Compass
Not Yet RecruitingPhase 4
Routine Use of Potassium Competitive Acid Blocker vs. Guideline-Directed Gastrointestinal Protection Strategy in Acute Myocardial Infarction
5,000 participantsStarted 2026-04-01
Plain-language summary
This study aims to compare the clinical outcomes between routine use of potassium competitive acid blocker (P-CAB) and guideline-directed gastrointestinal (GI) protection strategy in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI) and being treated with dual antiplatelet therapy (DAPT).
Who can participate
Age range19 Years
SexALL
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Inclusion Criteria:
* Patients aged 19 years or older.
* Patients diagnosed with acute myocardial infarction (ST-segment elevation myocardial infarction \[STEMI\] or non-ST-segment elevation myocardial infarction \[NSTEMI\]).
* Patients who underwent percutaneous coronary intervention (PCI) with drug-eluting stents (DES) or drug-coated balloons (DCB).
* Patients (or their legal representatives) who understood the study risks and benefits and provided voluntary written informed consent.
* Patients with suspected gastroesophageal reflux disease (GERD).
Exclusion Criteria:
* History of hypersensitivity (e.g., allergic reaction, anaphylactic shock) or contraindication to study drugs (potassium-competitive acid blocker \[P-CAB\] or proton pump inhibitor \[PPI\]).
* Presence of active gastrointestinal bleeding.
* Pregnant or breastfeeding women.
* Non-cardiac life expectancy of less than 1 year or patients expected to have low compliance (as determined by the investigator's medical judgment).
* Patients who refuse to participate or are unable to follow the requirements specified in the study protocol.